Welcome on www.ruloff-science.de! Optimized for Internet-Explorer.

… in business and science
Do you need new ideas?
Click here for contact!

Scientific publications    Dr. Robert Ruloff


Results of research activities at the University of Leipzig (Germany) and

the Swiss Federal Institute of Technology Lausanne - EPFL (Switzerland)

Organigramme : Procédé: The metallostar published in
Angew. Chem. Int. Ed., 2005
welcomes you on the website
of the School of Basic Science
at the Swiss Federal Institute
of Technology Lausanne – EPFL

… and it is cited by “C & EN”
volume 83, Number 10, p. 43;
Chemical & Engineering News
is the weekly magazine of the
- American Chemical Society -

in collaboration with research teams from:

      the University of Mons-Hainaut (Belgium), University of Essen (Germany),

      Utrecht University (The Netherlands), University of Brest (France),

      and Schering AG Berlin(Germany).


Zone de Texte:  
Print version of this page



   L. Lehmann, U. Niedballa, J. Platzek, M. Friebe, Ch.-S. Hilger,

     A. E. Merbach, E. Jakab-Toth, R. Ruloff, S. Laus

     WO 03/000647 A1 (Cl. C07C 229/16), 3 Jan 2003, Appl. 24 Jun 2002, 81 pp.

"(Ethylene)-(propylene)-triaminepentaacetic acid derivatives, process for their production,

 and their use for the production of pharmaceutical agents"


   A. E. Merbach, E. Jakab-Toth, R. Ruloff, S. Laus

     EP 1 277 728 A1 (Cl. C07C 229/16), 22 Jan 2003, Appl. 18 Jul 2001, 21 pp.

     "Novel TTDA derivatives and their use as gadolinium chelators for MRI imaging"


   R. Ruloff, M. Wagner, W. Gründer, E. Hoyer

     Ger. Offen. DE 44 06 465 A1 (Cl. A61K 49/00), 24 Aug 1995, Appl. 23 Feb 1994, 5 pp.

     "Kontrastmittel für die Kernspintomographie"


Book chapter


   R. Ruloff, Ch. Saudan, A. E. Merbach, F.-G. Klärner

In High Pressure Chemistry (Eds.: R. v. Eldik, F.-G. Klärner), Wiley-VCH, Weinheim, 2002, 348-368.

     Chapter 11 "Future Perspectives: Applications of High Pressure in Supramolecular Chemistry"




   J. Costa, R. Ruloff, L. Burai, L. Helm, A. E. Merbach

     J. Am. Chem. Soc., 2005, 127, 5147-5157.

"Rigid MIIL2Gd2II (M = Fe, Ru) complexes of a terpyridine based heteroditopic chelate: a class of candidates for MRI contrast agents"


   S. Laus, A. Sour, R. Ruloff, É. Tóth, A. E. Merbach

     Chem. Eur. J., accepted 25 Jan 2005, manuscript number: chem.200401326.

"Rotational dynamics accounts for pH-dependent relaxivities of dendrimeric Gd-based potential MRI contrast agents"


   E. Balogh, R. Tripier, R. Ruloff, É. Tóth

     Dalton Trans. 2005, 1058-1065.

"Kinetics of Formation and Dissociation of Lanthanide(III) Complexes with the 13-membered Macrocyclic Ligand TRITA4-"


   J. B. Livramento, É. Tóth, A. Sour, A. Borel, A. E. Merbach, R. Ruloff

     Angew. Chem. Int. Ed. 2005, 44, 1480-1484.          Angew. Chem. 2005, 117, 1504-1508.

     "High Relaxivity Confined to a Small Molecular Space: A Metallostar-based, Potential MRI Contrast Agent"


   R. Ruloff, G. van Koten, A. E. Merbach

     Chem. Commun. 2004, 842-843.

     "Novel Heteroditopic Chelate for Self-Assembled Gadolinium(III) Complex with High Relaxivity"


   S. Laus, R. Ruloff, É. Tóth, A. E. Merbach

     Chem. Eur. J. 2003, 9, 3555-3566.

"GdIII Complexes with Fast Water Exchange and High Thermodynamic Stability:

Potential Building Blocks for High-Relaxivity MRI Contrast Agents"


   R. Ruloff, É. Tóth, R. Scopelliti, R. Tripier, H. Handel, A. E. Merbach

     Chem. Commun. 2002, 2630-2631.

     "Accelerating Water Exchange for GdIII Chelates by Steric Compression Around the Water Binding Site"


   R. Ruloff, U. P. Seelbach, A. E. Merbach, F.-G. Klärner

     J. Phys. Org. Chem. 2002, 15, 189-196.

"Molecular Tweezers as Synthetic Receptors: The Effect of Pressure and Temperature

on the Formation of Host-Guest Complexes"


   R. Ruloff, Th. Gelbrich, E. Hoyer, J. Sieler, L. Beyer

     Z. Naturforsch., B: Chem. Sci. 1998, 53, 955-959.

"Controlled Crystallization of the Gadolinium(III) Complex of Diethylenetriamine-Pentaacetate:

Monomeric and Dimeric Structure"


   R. Ruloff, R. N. Muller, D. Pubanz, A. E. Merbach

     Inorg. Chim. Acta 1998, 275-276, 15-23.

"A Tripod Gadolinium(III) Poly(amino carboxylate) Relevant to Magnetic Resonance Imaging:

Structural and Dynamical 17O NMR and 1H NMRD Studies"


   R. Ruloff, R. Richter, L. Beyer

     Z. Anorg. Allg. Chem. 1998, 624, 902-908.

"The Trihydrochloride Monohydrate of N-(Pyrid-2-ylmethyl)ethylene-diamine-N,N',N'-triacetic Acid

and its Lanthanum(III) Complex"


   M. Wagner, R. Ruloff, E. Hoyer, W. Gründer

     Z. Naturforsch., C: J. Biosci. 1997, 52, 508-515.

     "New Gadolinium Complexes as Magnetic Resonance Imaging - Contrast Agents"


   R. Ruloff, Th. Gelbrich, J. Sieler, E. Hoyer, L. Beyer

     Z. Naturforsch., B: Chem. Sci. 1997, 52, 805-809.

"Structures of Two Isomeric Gadolinium(III) Polyamino Polycarboxylates -

Relation to their Significant Differences in 1H NMR Relaxation"


   R. Ruloff, P. Prokop, J. Sieler, E. Hoyer, L. Beyer

     Z. Naturforsch., B: Chem. Sci. 1996, 51, 963-968.

"Labilizing of a Carboxyl Group of the Coordinated Triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic Acid

(H6ttha): Coordination Numbers 10 for [La(Httha)]2- and 9 for [Dy(Httha)]2- in their Guanidinium Salts"


   R. Richter, Ch. Kunert, R. Ruloff, L. Beyer

     Z. Anorg. Allg. Chem. 1996, 622, 707-712.

"Molecular Structures of Copper(II) and Iron(III) Chloro Complexes with di- and mono-protonated

N-(Pyrid-2-ylmethyl)ethylenediamine-N,N',N'-triacetate (H2pedta-; Hpedta2-)"


   R. Ruloff, K. Arnold, L. Beyer, F. Dietze, W. Gründer, M. Wagner, E. Hoyer

     Z. Anorg. Allg. Chem. 1995, 621, 807-811.

"Chelate Formation of N-Tris(2-aminoethyl)amine-N',N',N'',N'',N''',N'''-hexaacetic Acid (H6TTAHA) and

N-(Pyrid-2-yl-methyl)ethylenediamine-N,N',N'-triacetic Acid (H3PEDTA) with Gadolinium(III) –

Syntheses, Stability Constants, and NMR Relaxivities"


   Updated: April 10, 2005               Copyright © 2005 Robert Ruloff. All rights reserved.